Sreekanth Vedagopuram

• Ph.D., UNESCO-Regional Centre for Biotechnology, India, degree awarded by Manipal Academy of Higher Education, 2018
• M.S. (Pharm.) with Medicinal Chemistry specialization, National Institute of Pharmaceutical Education and Research, India, 2010
• B.Pharmacy, Kakatiya University, India, 2008

Google Scholar Profile

ORCID Profile

• Sreekanth V, Jan M, Zhao KT, Lim D, Siriwongsup S, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A. A molecular glue approach to control the half-life of CRISPR-based technologies​. Journal of the American Chemical Society 2025, 147, 23844-23856 [Highlighted by: The Scientist] 
• Sreekanth V,* Sindi S,* Chaudhary SK,* Pergu R,* Singh P,* Karaj E,* Siriwongsup S, Fung JE, Deb A, DeCarlo SJ, Mercer JAM, Yamada K, Rodriguez D, Liu DR, and Choudhary A. Ultrasmall chemogenetic tags with group-transfer ligands. Angewandte Chemie International Edition 2025, e202506997
• Sabol AL,* Mengiste AA,* Singh P,* Sreekanth V,* Hendel SJ, Tran MTN, Barybin AM, Chaudhary S, Harris RM, Liivak K, Severance ZC, Locicero CM, Kailass K, Lee C, Xu LQ, Butty VL, Choudhary A, and Shoulders MD. Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells. Proceedings of the National Academy of Sciences U.S.A. 2026, 123, e2536003123
• Pergu R*, Sreekanth V*, Kokkonda P*, Lai S*, Tiwari PK*, Singh S*, Kawai J, Singha S, Tian W, Thimaradka V, Tran K, and Choudhary A. Phosphorylation-inducing molecules for regulating dynamic cellular processes. Journal of the American Chemical Society 2025, 147, 25316–25324
• Nyugen T,* Sreekanth V,* Deb A,* Kokkonda P,* Tiwari PK, Donovan KA, Shoba V, Chaudhary SK, Mercer JAM, Lai S, Sadagopan A, Jan M, Fischer ES, Liu DR, Ebert BL, Choudhary A. Proteolysis targeting chimeras with reduced off-targets. Nature Chemistry 2024, 16, 218-228 [Highlighted in: Communications Chemistry 2024, 7, 41.]
• Mercer JAM*, DeCarlo SJ*, Burman SSR*, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari P, Shoba V, Deb A, Choudhary A, Fischer ES, Liu DR. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 2024, 383, eadk4422
• Lim D,* Zhou Q,* Cox KJ,* Law BK,* Lee M,* Kokkonda P,* Sreekanth V,* Pergu, R, Chaudhary SK, S, Lai S, Amako Y, Thompson DB, Dančík V, Clemons PA, Wagner BK, Woo CM, Church GM, Choudhary A. A general approach to identify miniature, cell-permeable, and synthetic anti-CRISPRs. Nature Cell Biology 2022, 24, 1766-1775­­­­­
• Sreekanth V,* Zhou Q,* Kokkonda P,* Bermudez-Cabrera HC, Lim, D, Law BK, Chaudhary, S, Pergu, R, Holmes BR, Gifford DK, Sherwood RI, Choudhary A. Chemogenetic system demonstrates that Cas9 lifetime impacts genome-editing outcomes. ACS Central Science 2020, 6, 2228-2237
• Lim D, Sreekanth V, Cox KJ, Law B, Wagner BK, Karp JM, Choudhary A. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nature Communications 2020, 11, 4043 [Highlighted in: Faculty of 1000, Nature Bioengineering blog, Science in Boston]
• Sreekanth V,* Kar A,* Kumar S, Pal S, Sharma Y, Yadav P, Komalla V, Sharma H, Radheyshyam, Sharma RD, Mukhopadhyay A, Sengupta S, Dasgupta U, Bajaj A. Bile acid tethered docetaxel-based nanomicelles mitigate tumor progression through epigenetic changes. Angewandte Chemie International Edition 2021, 60, 5394-5399 [Highlighted in: India Science Wire, The Hindu, The Times of India, Delhi Post; First Author interview featured in: Bio Patrika]
• Sreekanth V, Pal S, Kumar S, Komalla V, Yadav P, Radheyshyam, Sengupta S, Bajaj A. Self-assembled supramolecular nanomicelles from bile acid-docetaxel conjugate are highly tolerable with improved therapeutic efficacy. Biomaterials Science 2021, 9, 5626-5639
• Sreekanth V, Bajaj A. Recent advances in engineering of lipid-drug conjugates for cancer therapy. ACS Biomaterials Science & Engineering 2019, 5, 4148-4166
• Sreekanth V, Medatwal N, Kumar S, Pal S, Malyla V, Kar A, Bhargava P, Naaz A, Kumar N, Sengupta S, Bajaj A. Tethering of chemotherapeutic drug/imaging agent to bile acid-phospholipid increases the efficacy and bioavailability with reduced hepatotoxicity. Bioconjugate Chemistry 2017, 28, 2942-2953
• Sreekanth V, Medatwal N, Pal S, Kumar S, Sengupta S, Bajaj A. Molecular self-assembly of bile acid-phospholipids controls the delivery of doxorubicin and mice survivability. Molecular Pharmaceutics 2017, 14, 2649-2659
• Sreekanth V,* Bansal S,* Motiani RK, Kundu S, Muppu SK, Majumdar TD, Panjamurthy K, Sengupta S, Bajaj A. Design, synthesis, and mechanistic investigations of bile acid-tamoxifen conjugates for breast cancer therapy. Bioconjugate Chemistry 2013, 24, 1468-1484

Honors/Awards/Achievements: 

• Junior and Senior Fellow (2011-16): Recipient of Junior and Senior Research Fellowships from the Regional Centre for Biotechnology, Faridabad, India.
• Institute Gold Medal 1 (2012): Awarded a gold medal for standing first in order of merit among all the departments at NIPER-Kolkata between 2008-10.
• Institute Gold Medal 2 (2012): Awarded a gold medal for standing first in order of merit in the Medicinal Chemistry Department at NIPER-Kolkata between 2008-10.
• Special Prize (2012): Recipient of a special prize for standing first among all the students (the best research presentation) at NIPER-Kolkata. 
• Junior Research Fellowship (2010-11): Recipient of Junior Research Fellowship from NIPER-Mohali, India.
• CSIR-LS-NET Fellow in Chemical Sciences (2009): Achieved All India-98 rank in the entrance exam conducted by the Council of Scientific and Industrial Research (CSIR), India.
• Merit Scholarship (2008-10): Recipient of a merit scholarship from the Ministry of Chemicals and Fertilizers, GOI, India to pursue M.S. at NIPER-Kolkata.
• GATE Fellow in Pharmaceutical Sciences (2008): Achieved All India-91 rank with 99.66 percentile in Graduate Aptitude Test in Engineering (GATE) conducted by Indian Institute of Science, Bangalore, India

Editorial Appointments:

• Ad hoc Reviewer for the journals: ChemComm, Nanoscale Horizons, Materials Horizons, ACS Omega, RSC Advances, Scientific Reports, Biomedical Materials, Frontiers in Nanotechnology, Frontiers in Pharmacology, Frontiers in Bioengineering and Biotechnology, Frontiers in Synthetic Biology, Frontiers in Aging Neuroscience, Molecules, International Journal of Nanomedicine, Pharmaceutics, Bioengineering.