Faculty Profile
Gregory Dudley
Professor and Dean, College of Natural Sciences and Mathematics
Department of Chemistry
Office: SR1, 214
Contact: gbdudley@uh.edu - 713-743-2611
Education: Ph.D., Massachusetts Institute of Technology, 2000
NIH Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, 2000-2002
Organic synthesis, reaction methodology and technology, and medicinal chemistry
The fundamental goal of the Dudley lab is to devise, develop, and apply new ideas
in organic chemistry to the efficient synthesis of complex molecules, particularly
natural products with medicinal applications. Natural products research impacts the
development of many important drugs including aspirin, penicillin, and Taxol. The
ability to recreate and refine the molecular architecture of complex natural products
through organic synthesis is key to understanding and ultimately leveraging these
systems to improve human health. Our research aims to enable advances in modern medicine
through innovations in the science and practice of organic synthesis.
• Eberly Family Distinguished Professorship, West Virginia University, 2016–2025
• Brown & Williamson Lecturer, University of Louisville, 2023
• Brodie Research Innovation Award, 2019–2020
• Syngenta Lecturer, Groupe D’Etudes de Chemie Organique 57, Ascain, France, 2016
• Organic Syntheses Lecturer, University of New Hampshire, 2012
• Raymond Cottrell Family Professor, 2008–2012
• Highlighted in Florida Trend Magazine, “Person to Watch”, 2010
• FSU Developing Scholar Award, 2010
• FSU Undergraduate Teaching Award, 2010
• FSU Innovator Award, 2006, 2007, 2008, 2010, 2012
• Featured in Tallahassee Magazine, “The New Establishment”, 2006
• NIH Postdoctoral Fellowship, 2000–2002
• Bristol-Myers Squibb Predoctoral Fellowship, 1999–2000
• Roche Award for Excellence in Organic Chemistry, 1999
• Boehringer Ingelheim Predoctoral Fellowship, 1997–1998
• MIT Chemistry Outreach Fellowship, 1997
Recent publications
- Tavakoli, A.; Dudley, G. B. Regioselective [2+2+2] Alkyne Cyclotrimerizations to Hexasubstituted Benzenes: Syntheses of Fomajorin D and Fomajorin S. J. Org. Chem. 2024, 89, 6847–6852.
- Wang, H.; Gaston, R., Jr.; Ahmed, K. T.; Dudley, G. B.; Barrios, A. M. Derivatives of the fungal natural product illudalic acid inhibit the activity of protein
histidine phosphatase PHPT1. ChemMedChem 2023, 18, e202300187.
- Highlighted in ChemistryViews.org as a Very Important Paper (VIP)
- Tavakoli, A.; Dudley, G. B. Synthesis of coprinol and several alcyopterosin sesquiterpenes by regioselective [2 + 2 + 2] alkyne cyclotrimerization. J. Org. Chem. 2022, 87, 14909–14914.
- Fulo, H. F.; Rueb, N. J.; Gaston, R., Jr.; Batsomboon, P.; Ahmed, K. T.; Barrios, A. M.; Dudley, G. B. Synthesis of illudalic acid and analogous phosphatase inhibitors. Org. Biomol. Chem. 2021, 19, 10596–10600.
- Fulo, H. F.; Shoeib, A.; Cabanlong, C. V.; Williams, A. H.; Zhan, C.-G.; Prather,
P. L.; Dudley, G. B. Synthesis, molecular pharmacology, and structure-activity relationships of 3-(indanoyl)indoles
as selective cannabinoid type 2 receptor antagonists. J. Med. Chem. 2021, 64, 6381–6396.
- Highlighted in Synfacts 2021, 17, 0816
- Gaston, R., Jr.; Geldenhuys, W. J.; Dudley, G. B. Synthesis of illudinine from dimedone and identification of activity as a monoamine
oxidase inhibitor. J. Org. Chem. 2020, 85, 13429–13437.
- Selected as a JOC Featured Article
- Tavakoli, A.; Stiegman, A. E.; Dudley, G. B. Mixed solvent system for selective microwave heating: accelerated thermal reaction
kinetics of a microwave-transparent substrate. Phys. Chem. Chem. Phys. 2022, 24, 2794–2799.
- Selected as a PCCP HOT Article
- Frasso, M. A.; Stiegman, A. E.; Dudley, G. B. Microwave-specific acceleration of a retro-Diels-Alder reaction. Chem. Commun. 2020, 56, 11247–11250.
- Featured in a Chemistry World news article